A Review of 3D / 4D / 5D Printing Applications for Biomedical Supply Chain

İbrahim Akben; Seval Akben

EN TR

A Review of 3D / 4D / 5D Printing Applications for Biomedical Supply Chain

Abstract

The objective of this study is to critically review the applications of 3D, 4D and 5D printing technologies in the biomedical supply chain. The evolution of additive manufacturing has significant impacts on the healthcare sector in terms of supply chain optimization, cost reduction and developing customized medical solutions. 3D printing revolutionized the production of advanced biomedical devices, organs and tissues by making patient-specific strategies possible. 4D printing has demonstrated significant advantages especially in producing medical implants, prosthetics and regenerative tissue by providing dynamic structures that react to environmental stimuli. The new 5D printing improves accuracy and complexity by virtue of its multi-axis production feature. This research analyzes the effect of such technologies on the change they induce in biomedical product production and supply chain. Besides, the future directions and challenges of such technologies are analyzed and how they can reshape healthcare models are debated.

Keywords

References

Acar, A. Z., & Bozaykut, B. (2017). Türk sağlık sektöründe tedarik zinciri yönetimine genel bir bakış. İşletme & Sosyal Bilimler Araştırmaları Dergisi, 6(5), 13-27.
Akbari, S., Sakhaeim, A. H., Kowsari, K., Yang, B., Serjouei, A., Yuanfang, Z., & Ge, Q. (2018). Enhanced multi-material 4D printing with active hinges. Smart Materials and Structures, 27(6), 1-23.
Akkuş, H. G. N., Günaydın, B. E., & Üstündağ, C. B. (2020). Doku mühendisliğinde 3 boyutlu biyo-baskı için biyofonksiyonel mürekkepler. International Journal of 3D Printing Technologies and Digital Industry, 4(3), 285-294.
Belleghem, S. V. (2024, September 1). How 3D printing is changing the customer relation. Retrieved from https://www.stevenvanbelleghem.com/blog/how-3d-printing-is-changing-the-customer-relation/
Biswas, M. C., Chakraborty, S., Bhattacharjee, A., & Mohammed, Z. (2021). 4D printing of shape memory materials for textiles: Mechanism, mathematical modeling, and challenges. Advanced Functional Materials, 2100257. https://doi.org/10.1002/adfm.202100257
Bodaghi, M., Damanpack, A. R., & Liao, W. H. (2018). Triple shape memory polymers by 4D printing. Smart Materials and Structures, 27, 1-16.
Bose, S., Vahabzadeh, S., & Bandyopadhyay, A. (2013). Bone tissue engineering using 3D printing. Materials Today, 16(12), 496-504. https://doi.org/10.1016/j.mattod.2013.11.017
Bowersox, D., Closs, D., & Cooper, M. B. (2002). Supply chain logistics management. New York: McGraw-Hill/Irwin.

Büyüközkan, G., & Vardaloğlu, Z. (2008). Yeşil tedarik zinciri yönetimi. Lojistik Dergisi, 8, 66-73.
Campbell, T., Williams, C., Ivanova, O., & Garrett, B. (2011). Could 3D printing change the world? Technologies, potential, and implications of additive manufacturing. Atlantic Council.
Carlota, V. (2023, February 2). 8 very promising bioprinting projects. Retrieved from https://www.3dnatives.com/en/bioprinting-projects-3d-printed-organs-070420205/#
Castro, N. J., Meinert, C., Levett, P., & Hutmacher, D. W. (2017). Current developments in multifunctional smart materials for 3D/4D bioprinting. Current Opinion in Biomedical Engineering, 2, 67-75.
Chae, M. P., Hunter-Smith, D. J., De-Silva, I., Tham, S., Spychal, R. T., & Rozen, W. M. (2015). Four-dimensional (4D) printing: A new evolution in computed tomography-guided stereolithographic modeling. Journal of Reconstructive Microsurgery, 31(6), 458–463.
Chia, H. N., & Wu, B. M. (2015). Recent advances in 3D printing of biomaterials. Journal of Biological Engineering, 9(4). https://doi.org/10.1186/s13036-015-0001-4
Choi, C. Q. (2024, September 13). 4D implant saves babies with breathing problems. Retrieved from https://www.livescience.com/50668-4d-implant-babies-breathing-problems.html
CSCMP (Council of Supply Chain Management Professionals). (2024, September 12). Retrieved from https://cscmp.org/CSCMP/Educate/SCM_Definitions_and_Glossary_of_Terms.aspx
Dawood, A., Marti, B., Sauret-Jackson, V., & Darwood, A. (2015). 3D printing in dentistry. British Dental Journal, 219, 521–529. https://doi.org/10.1038/sj.bdj.2015.914
De Vries, J., & Huijsman, R. (2011). Supply chain management in health services: An overview. Supply Chain Management, 16(3), 159-165. https://doi.org/10.1108/13598541111127146
Duhaime-Ross, A. (2024, April 17). 3D-printed airway splint saves three babies from imminent death. Retrieved from https://www.theverge.com/2015/4/29/8515501/3d-printed-splint-saves-children-tracheal-bronchomalacia
Durna, B. H. (2018). Doku mühendisliği geleceğin tedavi yöntemi olabilir mi? Retrieved from https://bilimvegelecek.com.tr/index.php/2018/09/23/doku-muhendisligi-gelecegin-tedavi-yontemi-olabilir-mi-2/
Erdoğuş, H. (2019). Biyomedikal uygulamalarda 4B baskı işlemi: Şekil hafızalı malzemelerin katmanlı imalat yöntemiyle üretilmesi. International Journal of 3D Printing Technologies and Digital Industry, 3(1), 86-93.
Ge, Q., Sakhaei, A. H., Lee, H., Dunn, C. K., Fang, N. X., & Dunn, M. L. (2016). Multi-material 4D printing with tailorable shape memory polymers. Scientific Reports, 6.
Gopinathan, J., & Noh, I. (2018). Recent trends in bioinks for 3D printing. Biomaterials Research, 22(11). https://doi.org/10.1186/s40824-018-0122-1
Gosnell, J., Pietila, T., Samuel, B. P., Kurup, H. K. N., Haw, M. P., & Vettukattil, J. J. (2016). Integration of computed tomography and three-dimensional echocardiography for hybrid three-dimensional printing in congenital heart disease. Journal of Digital Imaging, 29(6), 665–669.
Haq, I. U. (2023, September 2). 4D printed implant saved babies with breathing problems. Retrieved from http://computingcage.com/4d-implant-saves-babies-with-breathing-problems/
He, P., Zhao, J., Zhang, J., Li, B., Gou, Z., Gou, M., & Li, X. (2018). Bioprinting of skin constructs for wound healing. Burns & Trauma, 6(5), 1-10.
Healthcare Supply Chain. (2024, August 28). Retrieved from https://www.zukunft-krankenhaus-einkauf.de/blog/einkaufsgemeinschaft/
Hendrikson, W. J., Rouwkema, J., Clementi, F., Blitterswijk, C. A., Fare, S., & Moroni, L. (2017). Towards 4D printed scaffolds for tissue engineering: Exploiting 3D shape memory polymers to deliver time-controlled stimulus on cultured cells. Biofabrication, 9(3), 031001.
Javaid, M., Haleem, A., & Kumar, L. (2018). Current status and applications of 3D scanning in dentistry. Clinical Epidemiology and Global Health, 7(2), 228-233. https://doi.org/10.1016/j.cegh.2018.07.005
Javaid, M., & Haleem, A. (2019). 4D printing applications in medical field: A brief review. Clinical Epidemiology and Global Health, 7(3), 317-321. https://doi.org/10.1016/j.cegh.2018.09.007
Javaid, M., & Haleem, A. (2020). Significant advancements of 4D printing in the field of orthopaedics. Journal of Clinical Orthopaedics and Trauma, 11(4), 485-490. https://doi.org/10.1016/j.jcot.2020.04.021
Joshi, S., Rawat, K., Karunakaran, C., Rajamohan, V., Mathew, A. T., Koziol, K., Vijay Kumar Thakur, V. K., & Balan, A. S. S. (2020). 4D printing of materials for the future: Opportunities and challenges. Applied Materials Today, 18. https://doi.org/10.1016/j.apmt.2019.100490
Kesayak, B. (2024, September 12). 4D yazıcılar ve akıllı malzemeler. Türkiye’nin Endüstri 4.0 platformu. Retrieved from https://www.endustri40.com/4d-yazicilar-ve-akilli-malzemeler/
Khan, F. A., Celik, K. C., Oral, O., & Rennie, A. E. W. (2018). A short review on 4D printing. International Journal of 3D Printing Technologies and Digital Industry, 2(2), 59-67.
Khoo, Z. X., Teoh, J. E. M., Liu, Y., Chua, C. K., Yang, S., An, J., Leong, K., & Yeong, W. Y. (2015). 3D printing of smart materials: A review on recent progress in 4D printing. Virtual and Physical Prototyping, 10(3), 103–122.
Kuang, X., Chen, K., Dunn, C. K., Wu, J., Li, V. C. F., & Qi, H. J. (2018). 3D printing of highly stretchable, shape-memory, and self-healing elastomer toward novel 4D printing. ACS Applied Materials & Interfaces, 10(8), 7381−7388.
Kumar, A., Ozdamar, L., & Zhang, C. N. (2008). Supply chain redesign in the healthcare industry of Singapore. Supply Chain Management, 13(2), 95-103. https://doi.org/10.1108/13598540810860930
Kumar, S. B., Jeevamalar, J., Ramu, P., Suresh, G., & Senthilnathan, K. (2020). Evaluation in 4D printing – A review. Materials Today: Proceedings. https://doi.org/10.1016/j.matpr.2020.07.335
Lee, A. Y., An, J., & Chua, C. K. (2017). Two-way 4D printing: A review on the reversibility of 3D-printed shape memory materials. Engineering, 3(5), 663-674.
Li, Y., Zhang, F., Liu, Y., Liu, Y., & Leng, J. (2020). 4D printed shape memory polymers and their structures for biomedical applications. Science China Technological Sciences, 63, 545–560. https://doi.org/10.1007/s11431-019-1494-0
Long, D. (2012). Uluslararası lojistik küresel tedarik zinciri yönetimi (M. Tanyaş & M. Düzgün, Trans.). Springer. Mandon, C. A., Blum, L. J., & Marquette, C. A. (2017). 3D–4D printed objects: New bioactive material opportunities. Micromachines, 8(4). https://doi.org/10.3390/mi8040102
McKone-Sweet, K., Hamilton, P., & Willis, S. B. (2005). The ailing healthcare supply chain: A prescription for change. Journal of Supply Chain Management, 41(1), 4-17. https://doi.org/10.1111/j.1745-493X.2005.tb00180.x
Melocchi, A., Uboldi, M., Cerea, M., Foppoli, A., Maroni, A., Moutaharrik, S., Palugan, L., Zema, L., & Gazzaniga, A. (2021). Shape memory materials and 4D printing in pharmaceutics. Advanced Drug Delivery Reviews. https://doi.org/10.1016/j.addr.2021.03.013
Miao, S., Castro, N., Nowicki, M., Xia, L., Cui, H., Zhou, X., Zhu, W., Lee, S. J., Sarkar, K., Vozzi, G., Tabata, Y., Fisher, J., & Zhang, L. G. (2017). 4D printing of polymeric materials for tissue and organ regeneration. Materials Today, 20(10), 577-591.
Molitch-Hou, M. (2023, April 6). Four ways 4D printing is becoming a reality. Retrieved from https://www.engineering.com/story/four-ways-4d-printing-is-becoming-a-reality
Oropallo, W., & Piegl, L. A. (2016). Ten challenges in 3D printing. Engineering with Computers, 32, 135–148. https://doi.org/10.1007/s00366-015-0407-0
Pei, E., & Loh, G. H. (2018). Technological considerations for 4D printing: An overview. Progress in Additive Manufacturing, 3(1-2), 95–107.
Reddy, P. P. (2024, April 14). 4D technology for creating artificial organs. Retrieved from https://medium.com/@ppreddy576/4d-technology-for-creating-artificial-organs-94892aea7ee1
Sanjeet, H., & Albert, H. (2016). Improving the Fontan: Pre-surgical planning using four-dimensional (4D) flow, bio-mechanical modeling, and three-dimensional (3D) printing. Progress in Pediatric Cardiology, 43, 57-60. https://doi.org/10.1016/j.ppedcard.2016.07.012
Saunders, S. (2024, August 12). 4D printing technique could be used to develop 3D printed human organs for transplant patients. Retrieved from https://3dprint.com/196141/4d-printing-human-organs/
Scott, C. (2023, April 9). 3D printing used to create optimized surgical snake robot. Retrieved from https://3dprint.com/225191/3d-printed-surgical-snake-robot/
Supply Chain Management. (2021, April 5). Retrieved from http://shafeelaw.com/supply-chain-management/
Tufnell, N. (2024, April 19). Neurosurgeons successfully implant 3D printed skull. Science. Retrieved from https://www.wired.co.uk/article/3d-printed-skull
Yanamandra, R. (2018). Development of an integrated healthcare supply chain model. Supply Chain Forum: An International Journal, 19(2), 111-121. https://doi.org/10.1080/16258312.2018.1475823
Yi, H. G., Lee, H., & Cho, D. W. (2017). 3D printing of organs-on-chips. Bioengineering, 4(1). https://doi.org/10.3390/bioengineering4010010
Zarek, M., Mansour, N., Shapira, S., & Cohn, D. (2016). 4D printing of shape memory‐based personalized endoluminal medical devices. Macromolecular Rapid Communications, 38(2). https://doi.org/10.1002/marc.201600628
Zhao, T., Yu, R., Li, X., Cheng, B., Zhang, Y., Yang, X., Zhao, X., Zhao, Y., & Huang, W. (2018). 4D printing of shape memory polyurethane via stereolithography. European Polymer Journal, 101, 120-126. https://doi.org/10.1016/j.eurpolymj.2018.02.021

Details

Primary Language

English

Subjects

Production and Operations Management

Journal Section

Review

Authors

İbrahim Akben ^*
0000-0003-3268-0242
Türkiye

Seval Akben
0000-0003-2582-3524
Türkiye

Publication Date

April 18, 2025

Submission Date

March 2, 2025

Acceptance Date

April 9, 2025

Published in Issue

Year 1970 Volume: 10 Number: 1

IZ

https://izlik.org/JA64RJ46XS

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RIS / Bibtex

APA

Akben, İ., & Akben, S. (2025). A Review of 3D / 4D / 5D Printing Applications for Biomedical Supply Chain. Türk Sosyal Bilimler Araştırmaları Dergisi, 10(1), 54-68. https://izlik.org/JA64RJ46XS

A Review of 3D / 4D / 5D Printing Applications for Biomedical Supply Chain

A Review of 3D / 4D / 5D Printing Applications for Biomedical Supply Chain

Abstract

Keywords

Biyomedikal Tedarik Zinciri İçin 3D / 4D / 5D Baskı Uygulamalarının İncelenmesi

Öz

Anahtar Kelimeler

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

IZ

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