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Antidepresan İlaç Kullanımı ve İlişkili Faktörler: Türkiye ve Almanya Karşılaştırması

Year 2022, Volume: 5 Issue: 3, 12 - 19, 31.12.2022

Orhan Zengin Yasemin Aslan Leyla Kanmaz

https://doi.org/10.54537/tusebdergisi.1106047

Abstract

Amaç: Dünya Sağlık Örgütü’ne göre depresyon, global ölçekte yaygın görülen, küresel hastalık yükünü artıran ve ekonomik büyümeyi olumsuz etkileyen ruhsal bir bozukluktur. Bu çalışmanın amacı 2008-2019 yılları arasında Türkiye’de ve Almanya’da antidepresan ilaç kullanım düzeylerini ve antidepresan kullanımı ile ilişkili faktörleri ortaya koymaktır.
Gereç ve Yöntemler: Veriler Organization for Economic Co-operation and Development (OECD) veri tabanından elde edilmiştir. Verilerin analizinde tanımlayıcı istatistiklerden yararlanılmıştır. Buna ek olarak, antidepresan ilaç kullanımı ile intihar, alkol ve uyuşturucu kaynaklı ölüm, alkol tüketimi ve intihar oranı arasındaki ilişkiyi saptamak amacıyla Spearman Korelasyon Testi ve iki ülke arasındaki farklılıkları ortaya koymak amacıyla Mann Whitney-U testi kullanılmıştır.
Bulgular: Ülkelere göre değişkenlerin aldığı değerlerin ortalama dağılımına bakıldığında; Almanya'da antidepresan ilaç kullanımının Türkiye'ye göre daha yüksek olduğu tespit edilmiştir. Antidepresan ilaç kullanımı ile intihar-alkol-uyuşturucu kaynaklı ölüm, alkol tüketimi ve intihar oranı arasında pozitif yönde güçlü bir ilişki saptanmıştır. Ülkelere göre antidepresan ilaç kullanımı ile intihar-alkol ve uyuşturucu kaynaklı ölüm, alkol tüketimi ve intihar oranı arasında istatistiksel olarak anlamlı bir fark saptanmıştır (p<0,05). Antidepresan ilaç kullanımı, intihar-alkol-uyuşturucu kaynaklı ölüm, alkol tüketimi ve intihar oranı Almanya’da Türkiye’ye kıyasla daha yüksek bulunmuştur.
Sonuç: Araştırma sonucunda Türkiye ve Almanya için intihar-alkol-uyuşturucu kaynaklı ölüm, alkol tüketimi ve intihar oranı arttıkça antidepresan ilaç kullanım oranının arttığı tespit edilmiştir. Küresel ölçekte depresyon yükünün azaltılması ülke düzeyinde politika yapıcılar, toplum, sağlık profesyonelleri ve araştırmacılar gibi çeşitli paydaşların iş birliğine dayalı ortak eylemini gerektirmektedir.

Keywords

Antidepresan ilaç kullanımı; Türkiye Almanya

Supporting Institution

Çalışmayı destekleyen herhangi bir kurum bulunmamaktadır.

References

  • Boden, J.M. & Fergusson, D.M. (2011). Alcohol and depression. Addiction, 106(5), 906-914. DOI: 10.1111/j.1360-0443.2010.03351.x.
  • Brody, D.J. & Gu, Q. (2020). Antidepressant use among adults: United States, 2015–2018. NCHS Data Brief, No. 377, 1-8.
  • Cipriani, A., Furukawa, T.A., Salanti, G., Chaimani, A., Atkinson, L.Z., Ogawa, Y,. ve diğerleri. (2018). Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: A systematic review and network meta-analysis. Lancet, 391(10128), 1357–1366.
  • COVID-19 Mental Disorders Collaborators. (2021). Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic. Lancet, 398(10312): 1700-1712. DOI: 10.1016/S0140-6736(21)02143-7.
  • Evans-Lacko, S., Aguilar-Gaxiola, S., Al-Hamzawi, A, Alonso, J., Benjet, C., Bruffaerts, R., ve diğerleri. (2018). Socio-economic variations in the mental health treatment gap for people with anxiety, mood, and substance use disorders: results from the WHO World Mental Health (WMH) surveys. Psychol Med, 48(9), 1560-1571. DOI: 10.1017/S0033291717003336.
  • GBD 2017 SDG Collaborators. (2018). Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related sustainable development goals for 195 countries and territories: A systematic analysis for the Global Burden of Disease Study 2017. Lancet, 392(10159), 2091–138.
  • GBD 2019 Disease and Injuries Collaborators. (2020). Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet, 396, 1204-1222.
  • Gibbons, R.D., Hur, K., Bhaumik, D.K., & Mann, J.J. (2005). The Relationship Between Antidepressant Medication Use and Rate of Suicide. Arch Gen Psychiatry, 62(2), 165–172. DOI:10.1001/archpsyc.62.2.165
  • Gould, S., & Friedman, L,F. (2016). Something startling is going on with antidepressant use around the World. https://www.businessinsider.com/countries-largest-antidepressant-drug-users-2016-2. adresinden elde edildi. Erişim tarihi: (06.04.2022).
  • Graham, K. & Massak, A. (2007). Alcohol consumption and the use of antidepressants. CMAJ, 176 (5) 633-637; DOI: DOI: 10.1503/cmaj.060446
  • Gusmão, R., Quintão, S., McDaid, D., Arensman, E., Van Audenhove, C., ve diğerleri. (2013) Antidepressant utilization and suicide in Europe: an ecological multi-national study. PLOS ONE, 8(6), e66455. DOI: 10.1371/journal.pone.0066455
  • Herrman, H., Patel, V., Kieling, C., Berk, M., Buchweitz, C., Cuijpers, P., ve diğerleri. (2022). Time for united action on depression: a Lancet-World Psychiatric Association Commission. Lancet, 399(10328), 957-1022. DOI: 10.1016/S0140-6736(21)02141-3.
  • Institute of Health Metrics and Evaluation. Global health data exchange (GHDx). http://ghdx.healthdata.org/gbd-results-tool?params=gbd-api-2019-permalink/d780dffbe8a381b25e1416884959e88b adresinden elde edildi. Erişim Tarihi: (05.04. 2022).
  • Ludwig, J., & Marcotte, D E. (2005). Anti-depressants, suicide, and drug regulation. J Policy Anal Manage, 24(2), 249-272. DOI: 10.1002/pam.20089.
  • Morgan, O. W., Griffiths, C., & Majeed, A. (2004). Association between mortality from suicide in England and antidepressant prescribing: an ecological study. BMC public health, 4, 63. DOI: 10.1186/1471-2458-4-63.
  • Nischal A, Tripathi A, Nischal A, Trivedi JK. (2012). Suicide and antidepressants: what current evidence ındicates. Mens Sana Monogr, 10, 33-44.
  • Olfson M, Shaffer D., Marcus, S.C., & Greenberg, T. (2003). Relationship between antidepressant medication treatment and suicide in adolescents. Arch Gen Psychiatry, 60(10), 978–982. doi:10.1001/archpsyc.60.9.978
  • Statista. (2022). Consumption of antidepressants in selected countries as of 2020*(in DDD per 1,000 inhabitants). https://www.statista.com/statistics/283072/antidepressant-consumption-in-selected-countries/ adresinden elde edildi. Erişim tarihi: (06.04.2022).
  • Subramaniam, M., He, V.Y., Vaingankar, J.A., Abdin, E., & Chong, S.A. (2013). Prevalence of and factors related to the use of antidepressants and benzodiazepines: results from the Singapore Mental Health Study. BMC Psychiatry 13, 231. DOI: 10.1186/1471-244X-13-231.
  • Substance Abuse and Mental Health Services Administration. (2019). Key substance use and mental health indicators in the United States: Results from the 2018 National Survey on Drug Use and Health (HHS Publication No. PEP19-5068, NSDUH Series H-54). Rockville, MD: Center for Behavioral Health Statistics and Quality.
  • Torres, N.P.B., Alvares-Teodoro, Juliana., Júnior, A.A.G., Barbosa, M.M., & Acurcio, F.A. (2022). Social and economic factors associated with antidepressant use: Results of a national survey in primary care. Journal of Affective Disorders Reports, 8(2022). DOI: 10.1016/j.jadr.2021.100307.
  • Valuck, R.J., Libby, A.M., Sills, M.R., Giese, A.A., & Allen, R.R. (2004). Antidepressant treatment and risk of suicide attempt by adolescents with major depressive disorder. CNS Drugs 18, 1119–1132. DOI: 10.2165/00023210-200418150-00006.
  • World Health Organization (WHO). (2021). Depression. Depression (who.int) dresinden elde edildi. Erişim tarihi: (05.04.2022).

Antidepressant Medication Usage and Associated Factors: Comparison of Turkey and Germany

Year 2022, Volume: 5 Issue: 3, 12 - 19, 31.12.2022

Orhan Zengin Yasemin Aslan Leyla Kanmaz

https://doi.org/10.54537/tusebdergisi.1106047

Abstract

Aim: According to the World Health Organization, depression is a mental disorder that is common globally, and increases the global burden of disease, and negatively affects economic growth. The aim of this study is to reveal the levels of antidepressant medication usage and the factors associated with antidepressant use in Turkey and Germany between 2008 and 2019.
Materials and Methods: Data were obtained from the Organization for Economic Co-operation and Development (OECD) database. Descriptive statistics were used for data analysis. Spearman Correlation Test was used to determine the relationship between antidepressant medication usage and suicide-alcohol-drug related death, alcohol consumption and suicide rate, and Mann Whitney-U test was used to reveal the differences between the two countries.
Results: Considering the average distribution of the values of the variables according to the countries; it was detected that the usage of antidepressant medications in Germany is higher than in Turkey. A strong positively correlation was detected between the usage of antidepressant medications and suicide-alcohol-drug related death, alcohol consumption, and suicide rates. A statistically significant difference was found between the usage of antidepressant medications and suicide-alcohol-drug related death, alcohol consumption and suicide rates by country (p<0.05). Antidepressant medication usage, suicide-alcohol-drug related death, alcohol consumption and suicide rates were found to be higher in Germany compared to Turkey.
Conclusion: As a result of the research, it was determined that as suicide-alcohol-drug related death, alcohol consumption, and suicide rates increase, as the rate of antidepressant medication usage increases for Turkey and Germany. Reducing the burden of depression on globally requires collaboration between various stakeholders, such as policy makers, the community, health professionals, and researchers.

Keywords

Antidepressant medication usage Turkey Germany

References

  • Boden, J.M. & Fergusson, D.M. (2011). Alcohol and depression. Addiction, 106(5), 906-914. DOI: 10.1111/j.1360-0443.2010.03351.x.
  • Brody, D.J. & Gu, Q. (2020). Antidepressant use among adults: United States, 2015–2018. NCHS Data Brief, No. 377, 1-8.
  • Cipriani, A., Furukawa, T.A., Salanti, G., Chaimani, A., Atkinson, L.Z., Ogawa, Y,. ve diğerleri. (2018). Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: A systematic review and network meta-analysis. Lancet, 391(10128), 1357–1366.
  • COVID-19 Mental Disorders Collaborators. (2021). Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic. Lancet, 398(10312): 1700-1712. DOI: 10.1016/S0140-6736(21)02143-7.
  • Evans-Lacko, S., Aguilar-Gaxiola, S., Al-Hamzawi, A, Alonso, J., Benjet, C., Bruffaerts, R., ve diğerleri. (2018). Socio-economic variations in the mental health treatment gap for people with anxiety, mood, and substance use disorders: results from the WHO World Mental Health (WMH) surveys. Psychol Med, 48(9), 1560-1571. DOI: 10.1017/S0033291717003336.
  • GBD 2017 SDG Collaborators. (2018). Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related sustainable development goals for 195 countries and territories: A systematic analysis for the Global Burden of Disease Study 2017. Lancet, 392(10159), 2091–138.
  • GBD 2019 Disease and Injuries Collaborators. (2020). Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet, 396, 1204-1222.
  • Gibbons, R.D., Hur, K., Bhaumik, D.K., & Mann, J.J. (2005). The Relationship Between Antidepressant Medication Use and Rate of Suicide. Arch Gen Psychiatry, 62(2), 165–172. DOI:10.1001/archpsyc.62.2.165
  • Gould, S., & Friedman, L,F. (2016). Something startling is going on with antidepressant use around the World. https://www.businessinsider.com/countries-largest-antidepressant-drug-users-2016-2. adresinden elde edildi. Erişim tarihi: (06.04.2022).
  • Graham, K. & Massak, A. (2007). Alcohol consumption and the use of antidepressants. CMAJ, 176 (5) 633-637; DOI: DOI: 10.1503/cmaj.060446
  • Gusmão, R., Quintão, S., McDaid, D., Arensman, E., Van Audenhove, C., ve diğerleri. (2013) Antidepressant utilization and suicide in Europe: an ecological multi-national study. PLOS ONE, 8(6), e66455. DOI: 10.1371/journal.pone.0066455
  • Herrman, H., Patel, V., Kieling, C., Berk, M., Buchweitz, C., Cuijpers, P., ve diğerleri. (2022). Time for united action on depression: a Lancet-World Psychiatric Association Commission. Lancet, 399(10328), 957-1022. DOI: 10.1016/S0140-6736(21)02141-3.
  • Institute of Health Metrics and Evaluation. Global health data exchange (GHDx). http://ghdx.healthdata.org/gbd-results-tool?params=gbd-api-2019-permalink/d780dffbe8a381b25e1416884959e88b adresinden elde edildi. Erişim Tarihi: (05.04. 2022).
  • Ludwig, J., & Marcotte, D E. (2005). Anti-depressants, suicide, and drug regulation. J Policy Anal Manage, 24(2), 249-272. DOI: 10.1002/pam.20089.
  • Morgan, O. W., Griffiths, C., & Majeed, A. (2004). Association between mortality from suicide in England and antidepressant prescribing: an ecological study. BMC public health, 4, 63. DOI: 10.1186/1471-2458-4-63.
  • Nischal A, Tripathi A, Nischal A, Trivedi JK. (2012). Suicide and antidepressants: what current evidence ındicates. Mens Sana Monogr, 10, 33-44.
  • Olfson M, Shaffer D., Marcus, S.C., & Greenberg, T. (2003). Relationship between antidepressant medication treatment and suicide in adolescents. Arch Gen Psychiatry, 60(10), 978–982. doi:10.1001/archpsyc.60.9.978
  • Statista. (2022). Consumption of antidepressants in selected countries as of 2020*(in DDD per 1,000 inhabitants). https://www.statista.com/statistics/283072/antidepressant-consumption-in-selected-countries/ adresinden elde edildi. Erişim tarihi: (06.04.2022).
  • Subramaniam, M., He, V.Y., Vaingankar, J.A., Abdin, E., & Chong, S.A. (2013). Prevalence of and factors related to the use of antidepressants and benzodiazepines: results from the Singapore Mental Health Study. BMC Psychiatry 13, 231. DOI: 10.1186/1471-244X-13-231.
  • Substance Abuse and Mental Health Services Administration. (2019). Key substance use and mental health indicators in the United States: Results from the 2018 National Survey on Drug Use and Health (HHS Publication No. PEP19-5068, NSDUH Series H-54). Rockville, MD: Center for Behavioral Health Statistics and Quality.
  • Torres, N.P.B., Alvares-Teodoro, Juliana., Júnior, A.A.G., Barbosa, M.M., & Acurcio, F.A. (2022). Social and economic factors associated with antidepressant use: Results of a national survey in primary care. Journal of Affective Disorders Reports, 8(2022). DOI: 10.1016/j.jadr.2021.100307.
  • Valuck, R.J., Libby, A.M., Sills, M.R., Giese, A.A., & Allen, R.R. (2004). Antidepressant treatment and risk of suicide attempt by adolescents with major depressive disorder. CNS Drugs 18, 1119–1132. DOI: 10.2165/00023210-200418150-00006.
  • World Health Organization (WHO). (2021). Depression. Depression (who.int) dresinden elde edildi. Erişim tarihi: (05.04.2022).
There are 23 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Araştırma Makaleleri
Authors

Orhan Zengin 0000-0002-0701-6019

Yasemin Aslan 0000-0001-6292-2332

Leyla Kanmaz 0000-0002-7426-5269

Publication Date December 31, 2022
Published in Issue Year 2022 Volume: 5 Issue: 3

Cite

APA Zengin, O., Aslan, Y., & Kanmaz, L. (2022). Antidepresan İlaç Kullanımı ve İlişkili Faktörler: Türkiye ve Almanya Karşılaştırması. Türkiye Sağlık Enstitüleri Başkanlığı Dergisi, 5(3), 12-19. https://doi.org/10.54537/tusebdergisi.1106047