Research Article
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Smart Bandage System: A Combination Of Chitosan, Nanoparticles And Electric Stimulation

Year 2021, Volume: 2 Issue: 1, 29 - 37, 02.07.2021

Rezzan Yardımcı Mahmed Sari Njjar Ahmet Koluman

Abstract

Diabetes mellitus, the world's fastest growing chronic disease, still affects more than 420 million people around the world. For years, many patients continue their lives with these diabetic wounds or lose their limbs mostly due to infection, against all countermeasures taken which are a long and painful treatments. For such chronic wounds, passive dressing treatments are accepted to be not very effective. In this study, a dressing system was developed for the improvement of healing time in chronic and diabetic wounds. The designed system has combined the effectiveness of bioelectric stimulation and the clinical effects of chitosan to accelerate wound healing process. The dressing system was obtained by bringing these two systems together. The designed chitosan films form the inner surface layer of dressing, while the electro stimulation circuit electrodes are at the ends of the dressing. When sending current pulses to the tissue surface during treatment current could pass through the chitosan films. Therefore, the current flowing through chitosan films was also measured in this study

Keywords

Chitosan, Chitosan Films, Electrical Stimulation, Wound Dressing, Diabetes mellitus.

Supporting Institution

TUBITAK

Project Number

1919B011901865

References

  • [1] Aygıt, C., Top, H. (2003). Diyabetik ayak ülserinde yara bakımı ve cerrahi girişimler. Turk J Plast Surg. 11(3), 153-158.
  • [2] Robert, G.F., Minelli, B. (2015). Challenges in the treatment of chronic wounds advances in wound care.
  • [3] Nunan, R., Harding, K.G., Martin, P. (2014). Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity. Dis Model Mech. 7, 1205–1213.
  • [4] Barakat, M., Di Pietro, L.A., Chen, L. (2020). Limited treatment options for diabetic wounds: barriers to clinical translation despite therapeutic success in murine models. Advances in Wound Care. 10(8), 436-460.
  • [5] Parsak, C., Samman, G., Çeli̇k, Ü. (2007) Yara iyileşmesi, yara bakımı ve komplikasyonları. Arşiv Kaynak Tarama Dergisi. 16(2), 145-159.
  • [6] Demi̇r, A., Kelahmetoğlu, O., Kelis, M. (2011). Yara iyileşmesinde elektrik stimulasyonu uygulaması. Journal of Experimental and Clinical Medicine. 27(4), 160-163.
  • [7] Farber, P.L., Isoldi, F.C., Ferreira, L.M. (2019). Electric factors in wound healing. Advances in Wound Care. 10(8).
  • [8] Gupta, B., Agarwal, R., Alam, M., (2010). Textile-based smart wound dressings. 35, 174–187.
  • [9] Blanco-Fernandez, B., Castaño, O. (2019). Ángel Mateos-Timoneda, M., Engel, E., Pérez-Amodio, S. Nanotechnology approaches in chronic wound healing. Advances in Wound Care. 10(5) , 234-256.
  • [10] Perez-Amodio, S., Rubio, N., Vila, O.F., Navarro-Requena, C., Castaño, O., Sanchez-Ferrero, A., Marti-Munoz, J., Alsina-Gibert, M., Blanco, J., Engel, E. (2020). Polymeric composite dressings containing calcium-releasing nanoparticles accelerate wound healing in diabetic mice. Advances in Wound Care, 10(6), 301-316.
  • [11] Thakral, G., Lafontaine, J., Najafi, B., Talal, T.K., Kim, P., Lavery, L.A. (2013). Electrical stimulation to accelerate wound healing. Diabet Foot Ankle. 4(1).
  • [12] Souza, D.C., Gaiotto, M.C., Neto, G.N.N., Castro, M.C.F., Nohama, P. (2017). Power amplifier circuits for functional electrical stimulation systems. Research on Biomedical Engineering. 33(2), 144-155.
  • [13] Snyder, R.J., Kirsner, R.S., Warriner, R.A., Lavery, L.A., Hanft, J.R., Sheehan, P. (2010). Consensus recommendations on advancing the standard of care for treating neuropathic foot ulcers in patients with diabetes. Ostomy Wound Manag. 56, 1–24.
  • [14] Suh, H., Petrofsky, J., Fish, A., Hernandez, V., Mendoza, E., Collins, K., Yang, T., Abdul, A., Batt, J., Lawson, D. (2009). A new electrode design to improve outcomes in the treatment of chronic non-healing wounds in diabetes. Diabetes Technol Ther. 11(5), 315-22.
  • [15] Isseroff, R.R., Dahle, S.E. (2012). Electrical stimulation therapy and wound healing: Where are we now? Adv. Wound Care 1, 238–243.
  • [16] Hampton, S., King, L. (2005). Healing an intractable wound using bio-electric stimulation therapy. Br. J. Nurs. 14, 30–32.
  • [17] Hampton, S., Collins, F. (2006). Treating a pressure ulcer with bio-electric stimulation therapy. Br. J. Nurs. 15, 14–18.
  • [18] Howe, D.S., Dunning, J., Zorman, C., Garverick, S.L, Bogie, K.M. (2015). Development of an integrated surface stimulation device for systematic evaluation of wound electrotherapy. Ann Biomed Eng. 43(2), 306-13.
  • [19] Kazancı, M., Yücel, N. (2019-2020). Loading ZnO nanoparticles into hepatized polynylalkol /chitosan hydrogels for wound dressing.
  • [20] Şahiner, M., Sağbaş, S., Turan, A., Erdugan, H., Şahiner, N. (2018). Yara kaplama malzemesi olarak kollajen esaslı hidrojel filmleri. Çanakkale Onsekiz Mart Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 4(2), 103-116.
  • [21] Şi̇mşek, T., Keyf, S. (2018). Alginat-kitosan bazlı biofilm sentezi için deneysel tasarım uygulaması. Karaelmas Fen ve Mühendislik Dergisi. 8(2), 482-490.
  • [22] Elbadawy, A., Kamoun, X.C., Mohamed, S., Mohy Eldin, M.S., S. Kenawy, El-Refaie. (2014). Crosslinked poly (vinyl alcohol) hydrogels for wound dressing applications: A review of remarkably blended polymers. Arabian Journal of Chemistry. 8(1), 1-14.
  • [23] Onbaşli, D., Çelik, G.Y., Durbilmez, G.D., Öçsoy, İ. (2018). Kitosan-gümüş nanopartikülü ve kitosan-gümüş-grafen oksit nanokompozitinin sentezi, karakterizasyonu ve antimikrobiyal aktivitelerinin belirlenmesi. Erciyes Üniversitesi Veteriner Fakültesi Dergisi. 15(3), 208 - 215.
  • [24] Yardımcı, R., Njjar, M.S., Koluman, A. (2020). Smart wound dressing concept. 3rd International New York Conference on Evolving Trends in Interdisciplinary Research & Practices. 14-20.

Akıllı Pansuman Sistemi: Kitosan, Nanopartiküller ve Elektrik Stimülasyon Kombinasyonu

Year 2021, Volume: 2 Issue: 1, 29 - 37, 02.07.2021

Rezzan Yardımcı Mahmed Sari Njjar Ahmet Koluman

Abstract

Dünyanın en hızlı artan kronik hastalığı olan şeker hastalığı, halen dünya çapında 420 milyondan fazla insanı etkilemektedir. Uzun ve ağrılı bir tedaviyle birçok hasta yıllardır diyabetik yaralarla hayatına devam etmekte ve çoğunlukla hastalar enfeksiyon nedeniyle uzuvlarını kaybetmektedir. Bu tür kronik yaralar için pasif pansuman tedavilerinin çok etkili olmadığı kabul edilmektedir. Bu çalışmada, kronik ve diyabetik yaralarda iyileşme süresinin iyileştirilmesi için bir pansuman sistemi geliştirilmiştir. Tasarlanan sistem, yara iyileşme sürecini hızlandırmak için biyoelektrik stimülasyonun etkinliği ile kitosanın klinik etkilerini birleştirmiştir. Bu iki sistemin kombinasyonu ile pansuman sistemi elde edilmiştir. Tasarlanan kitosan filmler sargının iç yüzey katmanını oluştururken, elektro stimülasyon devresi elektrotları sargının uçlarındadır. Tedavi sırasında doku yüzeyine akım darbeleri gönderirken akım kitosan filmlerden geçebilir. Bu nedenle bu çalışmada aynı zamanda kitosan filmlerinden geçen akım ölçülmüştür.

Keywords

Kitosan Kitosan Filmleri Elektrik Stimülasyonu Pansuman Şeker Hastalığı

Project Number

1919B011901865

References

  • [1] Aygıt, C., Top, H. (2003). Diyabetik ayak ülserinde yara bakımı ve cerrahi girişimler. Turk J Plast Surg. 11(3), 153-158.
  • [2] Robert, G.F., Minelli, B. (2015). Challenges in the treatment of chronic wounds advances in wound care.
  • [3] Nunan, R., Harding, K.G., Martin, P. (2014). Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity. Dis Model Mech. 7, 1205–1213.
  • [4] Barakat, M., Di Pietro, L.A., Chen, L. (2020). Limited treatment options for diabetic wounds: barriers to clinical translation despite therapeutic success in murine models. Advances in Wound Care. 10(8), 436-460.
  • [5] Parsak, C., Samman, G., Çeli̇k, Ü. (2007) Yara iyileşmesi, yara bakımı ve komplikasyonları. Arşiv Kaynak Tarama Dergisi. 16(2), 145-159.
  • [6] Demi̇r, A., Kelahmetoğlu, O., Kelis, M. (2011). Yara iyileşmesinde elektrik stimulasyonu uygulaması. Journal of Experimental and Clinical Medicine. 27(4), 160-163.
  • [7] Farber, P.L., Isoldi, F.C., Ferreira, L.M. (2019). Electric factors in wound healing. Advances in Wound Care. 10(8).
  • [8] Gupta, B., Agarwal, R., Alam, M., (2010). Textile-based smart wound dressings. 35, 174–187.
  • [9] Blanco-Fernandez, B., Castaño, O. (2019). Ángel Mateos-Timoneda, M., Engel, E., Pérez-Amodio, S. Nanotechnology approaches in chronic wound healing. Advances in Wound Care. 10(5) , 234-256.
  • [10] Perez-Amodio, S., Rubio, N., Vila, O.F., Navarro-Requena, C., Castaño, O., Sanchez-Ferrero, A., Marti-Munoz, J., Alsina-Gibert, M., Blanco, J., Engel, E. (2020). Polymeric composite dressings containing calcium-releasing nanoparticles accelerate wound healing in diabetic mice. Advances in Wound Care, 10(6), 301-316.
  • [11] Thakral, G., Lafontaine, J., Najafi, B., Talal, T.K., Kim, P., Lavery, L.A. (2013). Electrical stimulation to accelerate wound healing. Diabet Foot Ankle. 4(1).
  • [12] Souza, D.C., Gaiotto, M.C., Neto, G.N.N., Castro, M.C.F., Nohama, P. (2017). Power amplifier circuits for functional electrical stimulation systems. Research on Biomedical Engineering. 33(2), 144-155.
  • [13] Snyder, R.J., Kirsner, R.S., Warriner, R.A., Lavery, L.A., Hanft, J.R., Sheehan, P. (2010). Consensus recommendations on advancing the standard of care for treating neuropathic foot ulcers in patients with diabetes. Ostomy Wound Manag. 56, 1–24.
  • [14] Suh, H., Petrofsky, J., Fish, A., Hernandez, V., Mendoza, E., Collins, K., Yang, T., Abdul, A., Batt, J., Lawson, D. (2009). A new electrode design to improve outcomes in the treatment of chronic non-healing wounds in diabetes. Diabetes Technol Ther. 11(5), 315-22.
  • [15] Isseroff, R.R., Dahle, S.E. (2012). Electrical stimulation therapy and wound healing: Where are we now? Adv. Wound Care 1, 238–243.
  • [16] Hampton, S., King, L. (2005). Healing an intractable wound using bio-electric stimulation therapy. Br. J. Nurs. 14, 30–32.
  • [17] Hampton, S., Collins, F. (2006). Treating a pressure ulcer with bio-electric stimulation therapy. Br. J. Nurs. 15, 14–18.
  • [18] Howe, D.S., Dunning, J., Zorman, C., Garverick, S.L, Bogie, K.M. (2015). Development of an integrated surface stimulation device for systematic evaluation of wound electrotherapy. Ann Biomed Eng. 43(2), 306-13.
  • [19] Kazancı, M., Yücel, N. (2019-2020). Loading ZnO nanoparticles into hepatized polynylalkol /chitosan hydrogels for wound dressing.
  • [20] Şahiner, M., Sağbaş, S., Turan, A., Erdugan, H., Şahiner, N. (2018). Yara kaplama malzemesi olarak kollajen esaslı hidrojel filmleri. Çanakkale Onsekiz Mart Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 4(2), 103-116.
  • [21] Şi̇mşek, T., Keyf, S. (2018). Alginat-kitosan bazlı biofilm sentezi için deneysel tasarım uygulaması. Karaelmas Fen ve Mühendislik Dergisi. 8(2), 482-490.
  • [22] Elbadawy, A., Kamoun, X.C., Mohamed, S., Mohy Eldin, M.S., S. Kenawy, El-Refaie. (2014). Crosslinked poly (vinyl alcohol) hydrogels for wound dressing applications: A review of remarkably blended polymers. Arabian Journal of Chemistry. 8(1), 1-14.
  • [23] Onbaşli, D., Çelik, G.Y., Durbilmez, G.D., Öçsoy, İ. (2018). Kitosan-gümüş nanopartikülü ve kitosan-gümüş-grafen oksit nanokompozitinin sentezi, karakterizasyonu ve antimikrobiyal aktivitelerinin belirlenmesi. Erciyes Üniversitesi Veteriner Fakültesi Dergisi. 15(3), 208 - 215.
  • [24] Yardımcı, R., Njjar, M.S., Koluman, A. (2020). Smart wound dressing concept. 3rd International New York Conference on Evolving Trends in Interdisciplinary Research & Practices. 14-20.
There are 24 citations in total.

Details

Primary Language English
Subjects Tissue Engineering, Biomaterial , Electrical Engineering, Nanotechnology
Journal Section Research Articles
Authors

Rezzan Yardımcı 0000-0002-7709-8718

Mahmed Sari Njjar 0000-0003-2494-1086

Ahmet Koluman 0000-0001-5308-8884

Project Number 1919B011901865
Publication Date July 2, 2021
Published in Issue Year 2021 Volume: 2 Issue: 1

Cite

APA Yardımcı, R., Njjar, M. S., & Koluman, A. (2021). Smart Bandage System: A Combination Of Chitosan, Nanoparticles And Electric Stimulation. Research Journal of Biomedical and Biotechnology, 2(1), 29-37.
AMA Yardımcı R, Njjar MS, Koluman A. Smart Bandage System: A Combination Of Chitosan, Nanoparticles And Electric Stimulation. RJBB. July 2021;2(1):29-37.
Chicago Yardımcı, Rezzan, Mahmed Sari Njjar, and Ahmet Koluman. “Smart Bandage System: A Combination Of Chitosan, Nanoparticles And Electric Stimulation”. Research Journal of Biomedical and Biotechnology 2, no. 1 (July 2021): 29-37.
EndNote Yardımcı R, Njjar MS, Koluman A (July 1, 2021) Smart Bandage System: A Combination Of Chitosan, Nanoparticles And Electric Stimulation. Research Journal of Biomedical and Biotechnology 2 1 29–37.
IEEE R. Yardımcı, M. S. Njjar, and A. Koluman, “Smart Bandage System: A Combination Of Chitosan, Nanoparticles And Electric Stimulation”, RJBB, vol. 2, no. 1, pp. 29–37, 2021.
ISNAD Yardımcı, Rezzan et al. “Smart Bandage System: A Combination Of Chitosan, Nanoparticles And Electric Stimulation”. Research Journal of Biomedical and Biotechnology 2/1 (July 2021), 29-37.
JAMA Yardımcı R, Njjar MS, Koluman A. Smart Bandage System: A Combination Of Chitosan, Nanoparticles And Electric Stimulation. RJBB. 2021;2:29–37.
MLA Yardımcı, Rezzan et al. “Smart Bandage System: A Combination Of Chitosan, Nanoparticles And Electric Stimulation”. Research Journal of Biomedical and Biotechnology, vol. 2, no. 1, 2021, pp. 29-37.
Vancouver Yardımcı R, Njjar MS, Koluman A. Smart Bandage System: A Combination Of Chitosan, Nanoparticles And Electric Stimulation. RJBB. 2021;2(1):29-37.
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