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Endoplazmik Retikulum Stresinin Psikiyatrideki Yeri

Year 2022, Volume: 2 Issue: 1, 63 - 74, 16.06.2022

Abstract

Psikiyatrik hastalıkların etyolojisinde bugüne kadar hücre içi çeşitli patofizyolojik mekanizmalar araştırma konusu olmuştur. Endoplazmik retikulum, hücre içinde bulunan ve bazı önemli homeostatik süreçlerde yer alan bir organeldir. Endoplazmik retikulum stresi, çeşitli uyaranlar sonucunda bu homeostatik mekanizmalarda meydana gelen değişimleri ifade etmektedir. Endoplazmik retikulum stresi bugüne kadar birçok hastalık için araştırma konusu olmuştur. Bu derlemede, psikiyatrik hastalıkların oluşumunda endoplazmik retikulum stresinin etkisinin güncel literatür verileri doğrultusunda tartışılması, olası patofizyolojik mekanizmaların aydınlatılması ve yeni tedavi seçeneklerinin geliştirilmesi hususlarında yapılacak çalışmalara ışık tutması amaçlanmıştır.

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The Role of Endoplasmic Reticulum Stress in Psychiatry

Year 2022, Volume: 2 Issue: 1, 63 - 74, 16.06.2022

Abstract

Various intracellular pathophysiological mechanisms have been the subject of research in the ethology of psychiatric diseases so far. The endoplasmic reticulum is an organelle located inside the cell and involved in some essential homeostatic processes. Endoplasmic reticulum stress refers to the changes that occur in these homeostatic mechanisms due to various stimuli. Endoplasmic reticulum stress has been the subject of research for many diseases until today. This review aims to discuss the effect of endoplasmic reticulum stress in the formation of psychiatric diseases in line with current literature data, illuminate possible pathophysiological mechanisms, and shed light on the studies to be done on the development of new treatment options.

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  • Hetz, C. (2012). The unfolded protein response: Controlling cell fate decisions under ER stress and beyond. Nature Reviews Molecular Cell Biology. Nature Publishing Group. https://doi.org/10.1038/nrm3270
  • Hill, M. N., Hellemans, K. G. C., Verma, P., Gorzalka, B. B. ve Weinberg, J. (2012, Ekim). Neurobiology of chronic mild stress: Parallels to major depression. Neuroscience and Biobehavioral Reviews. doi:10.1016/j.neubiorev.2012.07.001
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Details

Primary Language Turkish
Subjects Psychiatry
Journal Section Reviews
Authors

Mustafa Karaağaç 0000-0001-5737-5880

Publication Date June 16, 2022
Submission Date January 13, 2022
Published in Issue Year 2022 Volume: 2 Issue: 1

Cite

APA Karaağaç, M. (2022). Endoplazmik Retikulum Stresinin Psikiyatrideki Yeri. Current Research and Reviews in Psychology and Psychiatry, 2(1), 63-74.