Objective: This study aimed to investigate the relationships between preconception thyroid stimulating hormone (TSH) and thyroxine (T4) levels, as well as second-trimester alpha-fetoprotein (AFP) levels, and the severity of proteinuria in 24-hour urine samples from patients with preeclampsia.
Method: This retrospective analysis focused on preeclampsia patients categorized by proteinuria in 24-hour urine. Inclusion criteria involved patients aged 20-44 with singleton pregnancies diagnosed with preeclampsia and delivery after 20 weeks of gestation. Patients were divided into mild (0.3 to <2 g, n = 94), severe (2 to <5 g, n = 38), and massive (≥5 g, n = 11) proteinuria groups. Comparison included second-trimester AFP levels, preconception TSH, and maternal/neonatal outcomes.
Results: Second-trimester AFP levels increased with proteinuria severity (mild: 47.97 ng/ml; severe: 60.52 ng/ml; massive: 65.50 ng/ml [p<0.001]). AFP emerged as a significant independent predictor of severe proteinuria (odds ratio=1.041), while TSH was not predictive (odds ratio=1.098; p=0.463).
Conclusion: AFP proved to be a valuable marker for predicting proteinuria severity in 24-hour urine samples from preeclampsia patients, whereas preconception TSH was a less compelling predictor.
Primary Language | English |
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Subjects | Clinical Sciences (Other) |
Journal Section | Research Articles |
Authors | |
Publication Date | January 29, 2024 |
Submission Date | November 22, 2023 |
Acceptance Date | January 21, 2024 |
Published in Issue | Year 2024 Volume: 2 Issue: 1 |